PI16

Across TCGA cell cohorts, PI16 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,519 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PI16-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of myoblast fusion, and Viral process. Each is linked with PI16 in more than 5 cancer types. Because this analysis shows association rather than direction, both PI16-to-partner and partner-to-PI16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by PI16-low versus PI16-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PI16→partner) and Y-score (partner→PI16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of myoblast fusion →	+0.092	+0.270	<.001	.004	3	6
LARGE_INTESTINE	Negative regulation of myoblast fusion →	+0.083	+0.092	<.001	.001	3	6
LUNG_NSCLC_LUAD	Viral process →	+0.044	+0.140	<.001	<.001	3	6
LUNG_NSCLC_LUAD	Positive regulation of exosomal secretion →	+0.061	+0.115	.003	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Release of cytochrome c from mitochondria →	+0.098	+0.121	.002	.002	2	6
PANCREAS	Antiviral innate immune response →	+0.054	+0.473	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,519 associations by consensus.

Regulation of myoblast fusion by PI16 expression — URINARY_TRACT

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