PI15

Across TCGA patient cohorts, PI15 mutation is significantly associated with the RNA expression of many other genes, with 3,932 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI15-associated genes across cancer lineages are MIR4774, IDI1P2, and TMEM251. Each is linked with PI15 in more than 2 cancer types. Because this analysis shows association rather than direction, both PI15-to-partner and partner-to-PI15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4774 grouped by PI15-low versus PI15-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI15→partner) and Y-score (partner→PI15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	3
BLCA	IDI1P2 →	+0.041	+4.814	<.001	.003	3	3
UCEC	TMEM251 →	+0.464	+2.431	.001	.001	3	2
UCEC	ATP5PF →	+0.417	+2.021	.002	<.001	3	2
UCEC	EME1 →	+0.633	+3.949	<.001	<.001	3	2
UCEC	MRPL17 →	+0.276	+2.111	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,932 associations by consensus.

MIR4774 by PI15 expression — READ

Explore this box plot interactively →