PI15

Across TCGA patient cohorts, PI15 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PI15-associated genes across cancer lineages are ASNS, JNK_pT183_Y185, and p62 Lck ligand. Each is linked with PI15 in more than 2 cancer types. Because this analysis shows association rather than direction, both PI15-to-partner and partner-to-PI15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by PI15-low versus PI15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PI15→partner) and Y-score (partner→PI15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.262	+1.584	.044	.019	3	3
UCEC	JNK_pT183_Y185 →	-0.166	-1.571	.006	.019	3	2
UCEC	p62 Lck ligand →	+0.298	+2.321	.011	.001	3	2
UCEC	P-Cadherin →	-0.122	-3.321	.018	.009	3	2
UCEC	EGFR_pY1068 →	-0.198	-1.584	.028	.019	3	1
UCEC	Heregulin →	-0.104	-2.986	.018	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ASNS by PI15 expression — UCEC

Explore this box plot interactively →