PI15

Across TCGA cell cohorts, PI15 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,230 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PI15-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Translational initiation. Each is linked with PI15 in more than 13 cancer types. Because this analysis shows association rather than direction, both PI15-to-partner and partner-to-PI15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by PI15-low versus PI15-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PI15→partner) and Y-score (partner→PI15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.131	+0.682	<.001	<.001	3	14
STOMACH	Negative regulation of myoblast fusion →	+0.133	+0.682	<.001	<.001	3	14
OESOPHAGUS	Translational initiation →	+0.123	+1.115	<.001	.005	3	13
STOMACH	Negative regulation of gene expression, epigenetic →	+0.103	+1.044	<.001	<.001	3	12
STOMACH	Nucleic acid catabolic process →	+0.067	+1.125	<.001	<.001	3	12
BONE	Heterochromatin formation →	+0.072	+0.786	<.001	.003	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,230 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by PI15 expression — STOMACH

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