PHYKPL

Across TCGA cell cohorts, PHYKPL mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible PHYKPL-associated genes across cancer lineages are PADI6, SCGB1C1, and OR56A4. Each is linked with PHYKPL in more than 1 cancer types. Because this analysis shows association rather than direction, both PHYKPL-to-partner and partner-to-PHYKPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PADI6 grouped by PHYKPL-low versus PHYKPL-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYKPL→partner) and Y-score (partner→PHYKPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PADI6 →	+0.044	+4.217	<.001	.005	3	2
BREAST	SCGB1C1 →	+0.067	+5.169	<.001	.005	3	2
SOFT_TISSUE	OR56A4 →	+0.012	+4.977	<.001	.002	3	1
SOFT_TISSUE	BOD1L2 →	+0.005	+4.977	<.001	.002	3	1
BLOOD_Myeloma	WFDC11 →	+0.112	+4.754	<.001	<.001	3	1
BLOOD_Myeloma	PRAMEF15 →	+0.233	+3.906	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PADI6 by PHYKPL expression — URINARY_TRACT

Explore this box plot interactively →