PHYHIP

Across TCGA pan-cancer cohorts, PHYHIP Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PHYHIP data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher PHYHIP Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PHYHIP expression acts as an unfavorable survival marker.

MESO and SARC are the cancer types where PHYHIP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	III,IV	0.082	0.414	.007	6	view →
SARC	OS	Median	All	0.210	0.730	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

PHYHIP–MESO (DFS)

Open the MESO breakdown →