PHYHIP

Across TCGA patient cohorts, PHYHIP protein abundance is significantly associated with the RNA expression of many other genes, with 4,696 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PHYHIP-associated genes across cancer lineages are PPM1A, PROKR2, and LHX6. Each is linked with PHYHIP in more than 1 cancer types. Because this analysis shows association rather than direction, both PHYHIP-to-partner and partner-to-PHYHIP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHYHIP versus PPM1A in HNSC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYHIP→partner) and Y-score (partner→PHYHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PPM1A →	+0.799	+1.653	.004	.003	3	2
GBM	PROKR2 →	+0.247	+0.738	<.001	<.001	3	2
GBM	LHX6 →	+0.694	+0.899	<.001	<.001	3	2
HNSC	NCOA7 →	+1.141	+1.455	.004	<.001	3	2
HNSC	RTN4 →	+0.478	+1.247	.009	<.001	3	2
HNSC	FAM98A →	+0.587	+2.152	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,696 associations by consensus.

PHYHIP vs PPM1A — HNSC

Explore this scatter interactively →