PHYHIP

Across TCGA patient cohorts, PHYHIP mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHYHIP-associated genes across cancer lineages are MEK1, Myosin-IIa_pS1943, and SF2. Each is linked with PHYHIP in more than 1 cancer types. Because this analysis shows association rather than direction, both PHYHIP-to-partner and partner-to-PHYHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PHYHIP-low versus PHYHIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYHIP→partner) and Y-score (partner→PHYHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.413	+3.321	.015	.010	3	2
UCEC	Myosin-IIa_pS1943 →	+0.259	+2.598	.007	.006	3	2
UCEC	SF2 →	-0.109	-2.311	.032	.034	3	2
UCEC	ATM →	-0.581	-2.584	.005	.011	3	2
UCEC	EGFR_pY1068 →	-0.329	-3.700	.004	.001	3	1
UCEC	eIF4E →	+0.237	+2.584	.015	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

MEK1 by PHYHIP expression — UCEC

Explore this box plot interactively →