PHYHIP

Across TCGA cell cohorts, PHYHIP RNA expression is significantly associated with the go_rna of many other GO terms, with 3,600 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PHYHIP-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Regulation of myoblast fusion, and Adrenal gland development. Each is linked with PHYHIP in more than 10 cancer types. Because this analysis shows association rather than direction, both PHYHIP-to-partner and partner-to-PHYHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by PHYHIP-low versus PHYHIP-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYHIP→partner) and Y-score (partner→PHYHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of myoblast fusion →	+0.088	+1.294	<.001	<.001	3	11
LUNG_SCLC	Regulation of myoblast fusion →	+0.086	+1.180	<.001	.004	3	10
KIDNEY	Adrenal gland development →	+0.215	+0.420	<.001	.002	3	9
LARGE_INTESTINE	Positive regulation of intracellular transport →	+0.065	+0.251	<.001	.002	3	9
SOFT_TISSUE	Membrane biogenesis →	+0.074	+0.486	.001	.002	3	9
URINARY_TRACT	Protein localization to plasma membrane raft →	+0.172	+0.487	.003	.005	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,600 associations by consensus.

Negative regulation of myoblast fusion by PHYHIP expression — LUNG_SCLC

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