PHYHIP

Across TCGA cell cohorts, PHYHIP mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHYHIP-associated genes across cancer lineages are CRYAA, TLE7, and CLEC9A. Each is linked with PHYHIP in more than 1 cancer types. Because this analysis shows association rather than direction, both PHYHIP-to-partner and partner-to-PHYHIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYAA grouped by PHYHIP-low versus PHYHIP-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYHIP→partner) and Y-score (partner→PHYHIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CRYAA →	+0.049	+4.705	.006	.003	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1
LARGE_INTESTINE	CLEC9A →	+0.012	+4.977	<.001	.007	3	1
SKIN	GUCA2A →	+0.062	+4.273	.001	.006	3	1
SKIN	SPINK9 →	+0.043	+4.415	<.001	.007	3	1
BLOOD_Leukemia	TRIL →	+0.248	+4.350	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CRYAA by PHYHIP expression — BLOOD_Leukemia

Explore this box plot interactively →