PHYHD1

Across TCGA patient cohorts, PHYHD1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHYHD1-associated genes across cancer lineages are eEF2, MEK1, and PDK1_pS241. Each is linked with PHYHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHYHD1-to-partner and partner-to-PHYHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PHYHD1-low versus PHYHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYHD1→partner) and Y-score (partner→PHYHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.496	+3.169	.011	.020	3	1
UCEC	MEK1 →	+0.426	+3.169	.033	.020	3	1
UCEC	PDK1_pS241 →	+0.185	+3.183	.048	.010	3	1
UCEC	Caspase-7-cleavedD198 →	+0.981	+2.827	.002	.035	3	1
UCEC	EGFR_pY1068 →	-0.301	-3.169	.029	.020	2	1
UCEC	Cyclin-B1 →	+0.906	+3.169	.003	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eEF2 by PHYHD1 expression — UCEC

Explore this box plot interactively →