PHYHD1

Across TCGA cell cohorts, PHYHD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,473 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PHYHD1-associated GO terms across cancer lineages are Regulation of protein localization to plasma membrane, Positive regulation of signal transduction by p53 class mediator, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with PHYHD1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PHYHD1-to-partner and partner-to-PHYHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to plasma membrane grouped by PHYHD1-low versus PHYHD1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYHD1→partner) and Y-score (partner→PHYHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of protein localization to plasma membrane →	+0.046	+0.899	.002	.002	3	6
LARGE_INTESTINE	Positive regulation of signal transduction by p53 class mediator →	+0.048	+0.535	<.001	<.001	3	6
LARGE_INTESTINE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.065	+0.490	<.001	.002	3	6
LARGE_INTESTINE	Endosome to lysosome transport →	+0.053	+0.502	<.001	.001	3	6
SOFT_TISSUE	Regulation of cell division →	+0.080	+2.682	<.001	<.001	3	5
OVARY	Cellular extravasation →	-0.110	-2.433	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,473 associations by consensus.

Regulation of protein localization to plasma membrane by PHYHD1 expression — PANCREAS

Explore this box plot interactively →