PHYHD1

Across TCGA cell cohorts, PHYHD1 mutation is significantly associated with the mutation status of many other genes, with 785 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHYHD1-associated genes across cancer lineages are DDHD1, ELL2, and TTPAL. Each is linked with PHYHD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHYHD1-to-partner and partner-to-PHYHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DDHD1 grouped by PHYHD1-low versus PHYHD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHYHD1→partner) and Y-score (partner→PHYHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DDHD1 →	+4.479	+5.635	<.001	<.001	1	3
BLOOD_Leukemia	ELL2 →	+4.479	+5.635	<.001	<.001	1	3
BLOOD_Leukemia	TTPAL →	+4.894	+4.894	.004	.004	1	3
BLOOD_Leukemia	ATMIN →	+4.309	+4.560	.007	.007	1	2
BLOOD_Leukemia	SMAD3 →	+4.309	+4.560	.007	.007	1	2
BLOOD_Leukemia	CLP1 →	+5.479	+6.145	<.001	<.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 785 associations by consensus.

DDHD1 by PHYHD1 expression — BLOOD_Leukemia

Explore this box plot interactively →