PHTF2

Across TCGA cell cohorts, PHTF2 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHTF2-associated genes across cancer lineages are DEFB124, CCER1, and MAGEB5. Each is linked with PHTF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHTF2-to-partner and partner-to-PHTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB124 grouped by PHTF2-low versus PHTF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHTF2→partner) and Y-score (partner→PHTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFB124 →	+0.065	+2.669	<.001	.004	3	3
LARGE_INTESTINE	CCER1 →	+0.007	+2.977	<.001	.006	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	PIRT →	+0.006	+4.643	<.001	.008	3	1
LUNG_SCLC	IL17A →	+0.530	+4.044	<.001	.009	3	1
LUNG_SCLC	OR9G4 →	+0.099	+5.614	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

DEFB124 by PHTF2 expression — LARGE_INTESTINE

Explore this box plot interactively →