PHRF1

Across TCGA patient cohorts, PHRF1 RNA expression is significantly associated with the mutation status of many other genes, with 10,836 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHRF1-associated genes across cancer lineages are TP53, ZNF536, and RP1. Each is linked with PHRF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHRF1-to-partner and partner-to-PHRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TP53 grouped by PHRF1-low versus PHRF1-high in LIHC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHRF1→partner) and Y-score (partner→PHRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	TP53 →	+1.431	+0.335	<.001	<.001	3	4
READ	ZNF536 →	+3.377	+0.495	.003	<.001	3	4
READ	RP1 →	+3.188	+0.481	.009	.004	3	4
READ	SACS →	+3.225	+0.479	.007	.001	3	4
UCEC	FCGBP →	+1.425	+0.310	<.001	<.001	3	4
UCEC	ADGRG4 →	+1.233	+0.292	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,836 associations by consensus.

TP53 by PHRF1 expression — LIHC

Explore this box plot interactively →