PHRF1

Across TCGA patient cohorts, PHRF1 mutation is significantly associated with the RNA expression of many other genes, with 4,403 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHRF1-associated genes across cancer lineages are EXOSC9, HIRIP3, and FDXR. Each is linked with PHRF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHRF1-to-partner and partner-to-PHRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOSC9 grouped by PHRF1-low versus PHRF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHRF1→partner) and Y-score (partner→PHRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EXOSC9 →	+0.463	+3.183	<.001	<.001	3	4
COAD	HIRIP3 →	+0.518	+3.999	<.001	<.001	3	4
COAD	FDXR →	+0.589	+3.615	.001	.001	3	4
COAD	HPF1 →	+0.562	+2.906	<.001	.001	3	4
UCEC	NIPA1 →	+0.558	+1.731	<.001	<.001	3	4
UCEC	MRTO4 →	+0.248	+2.010	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,403 associations by consensus.

EXOSC9 by PHRF1 expression — COAD

Explore this box plot interactively →