PHRF1

Across TCGA patient cohorts, PHRF1 mutation is significantly associated with the total protein of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHRF1-associated genes across cancer lineages are PCNA, GSK-3a-b_pS21_S9, and eEF2. Each is linked with PHRF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHRF1-to-partner and partner-to-PHRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PHRF1-low versus PHRF1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHRF1→partner) and Y-score (partner→PHRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PCNA →	+0.298	+2.999	.003	.035	3	3
COAD	GSK-3a-b_pS21_S9 →	-0.333	-1.781	.022	.026	3	3
UCEC	eEF2 →	+0.222	+1.584	.028	.032	3	2
UCEC	eIF4E →	+0.217	+1.784	<.001	<.001	3	2
UCEC	GAPDH →	+0.343	+1.662	.024	.010	3	2
UCEC	NF2 →	+0.166	+1.415	.006	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

PCNA by PHRF1 expression — BLCA

Explore this box plot interactively →