PHRF1

Across TCGA cell cohorts, PHRF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,643 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHRF1-associated GO terms across cancer lineages are Telomere tethering at nuclear periphery, Telomere localization, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with PHRF1 in more than 16 cancer types. Because this analysis shows association rather than direction, both PHRF1-to-partner and partner-to-PHRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Telomere tethering at nuclear periphery grouped by PHRF1-low versus PHRF1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHRF1→partner) and Y-score (partner→PHRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Telomere tethering at nuclear periphery →	+0.162	+1.142	<.001	.001	3	17
OVARY	Telomere localization →	+0.224	+0.793	<.001	<.001	3	15
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.176	+0.952	.002	<.001	3	15
BONE	Nuclear export →	+0.105	+1.117	.001	.001	3	14
OESOPHAGUS	Methylglyoxal catabolic process →	+0.256	+1.335	<.001	<.001	3	14
LARGE_INTESTINE	Methylglyoxal metabolic process →	+0.094	+0.849	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,643 associations by consensus.

Telomere tethering at nuclear periphery by PHRF1 expression — STOMACH

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