PHRF1

Across TCGA cell cohorts, PHRF1 mutation is significantly associated with the RNA expression of many other genes, with 1,357 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHRF1-associated genes across cancer lineages are PDIK1L, NIPSNAP1, and TTC21B. Each is linked with PHRF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHRF1-to-partner and partner-to-PHRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDIK1L grouped by PHRF1-low versus PHRF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHRF1→partner) and Y-score (partner→PHRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDIK1L →	+0.608	+2.364	<.001	<.001	3	3
LARGE_INTESTINE	NIPSNAP1 →	+0.589	+2.364	.008	<.001	3	3
BLOOD_Leukemia	TTC21B →	+0.589	+3.228	<.001	.004	3	3
UPPER_AERODIGESTIVE_TRACT	TSPY8 →	+0.023	+5.357	<.001	.003	3	2
SKIN	CEP76 →	+0.635	+3.212	<.001	.006	3	2
LARGE_INTESTINE	GCAT →	+1.182	+2.364	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,357 associations by consensus.

PDIK1L by PHRF1 expression — LARGE_INTESTINE

Explore this box plot interactively →