PHPT1

Across TCGA patient cohorts, PHPT1 protein abundance is significantly associated with the RNA expression of many other genes, with 21,636 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PHPT1-associated genes across cancer lineages are PSMB2, CENPA, and CDC20. Each is linked with PHPT1 in more than 6 cancer types. Because this analysis shows association rather than direction, both PHPT1-to-partner and partner-to-PHPT1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHPT1 versus PSMB2 in LSCC, with a Pearson correlation of -0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHPT1→partner) and Y-score (partner→PHPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PSMB2 →	-0.564	-0.311	<.001	<.001	3	7
BRCA	CENPA →	-0.918	-0.473	<.001	<.001	3	7
LUAD	CDC20 →	-1.160	-0.348	<.001	<.001	3	7
BRCA	CENPF →	-1.019	-0.465	<.001	<.001	3	7
BRCA	CCNB1 →	-1.021	-0.505	<.001	<.001	3	7
LUAD	CDCA8 →	-0.850	-0.260	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,636 associations by consensus.

PHPT1 vs PSMB2 — LSCC

Explore this scatter interactively →