PHPT1

Across TCGA patient cohorts, PHPT1 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. CESC shows the largest number of these associations.

The most reproducible PHPT1-associated genes across cancer lineages are CENPVL1, PRAMEF1, and MBD3L3. Each is linked with PHPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHPT1-to-partner and partner-to-PHPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPVL1 grouped by PHPT1-low versus PHPT1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHPT1→partner) and Y-score (partner→PHPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CENPVL1 →	+0.019	+7.954	<.001	.008	3	1
CESC	PRAMEF1 →	+0.183	+5.345	<.001	.001	3	1
CESC	MBD3L3 →	+0.421	+5.144	<.001	.003	3	1
CESC	RNU1-4 →	+0.180	+5.837	<.001	.001	3	1
CESC	TRAJ61 →	+0.711	+5.345	<.001	.001	3	1
CESC	TRAJ53 →	+0.522	+4.812	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

CENPVL1 by PHPT1 expression — HNSC

Explore this box plot interactively →