PHPT1

Across TCGA cell cohorts, PHPT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,427 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PHPT1-associated GO terms across cancer lineages are Dolichyl monophosphate biosynthetic process, Iron-sulfur cluster assembly, and Metallo-sulfur cluster assembly. Each is linked with PHPT1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PHPT1-to-partner and partner-to-PHPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Dolichyl monophosphate biosynthetic process grouped by PHPT1-low versus PHPT1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHPT1→partner) and Y-score (partner→PHPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Dolichyl monophosphate biosynthetic process →	+0.086	+0.518	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Iron-sulfur cluster assembly →	+0.064	+0.671	<.001	.001	3	7
UPPER_AERODIGESTIVE_TRACT	Metallo-sulfur cluster assembly →	+0.064	+0.671	<.001	.001	3	7
OVARY	Proteasome regulatory particle assembly →	+0.085	+0.578	<.001	<.001	3	7
SKIN	Response to vitamin B1 →	+0.102	+0.459	<.001	.002	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of protein export from nucleus →	-0.154	-0.932	.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,427 associations by consensus.

Dolichyl monophosphate biosynthetic process by PHPT1 expression — BLOOD_Myeloma

Explore this box plot interactively →