PHOSPHO2

Across TCGA pan-cancer cohorts, PHOSPHO2 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PHOSPHO2 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher PHOSPHO2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PHOSPHO2 expression acts as an unfavorable survival marker.

UCS, LIHC, and LUSC are the cancer types where PHOSPHO2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Median	III,IV	0.102	0.591	<.001	24	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	12	view →
LUSC	OS	Median	III,IV	0.178	0.683	.040	6	view →
SKCM	OS	Median	III,IV	0.233	0.705	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PHOSPHO2–UCS (OS)

Open the UCS breakdown →