PHOSPHO2

Across TCGA patient cohorts, PHOSPHO2 mutation is significantly associated with the RNA expression of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHOSPHO2-associated genes across cancer lineages are IGHD5-12, RN7SL578P, and EIF3JP1. Each is linked with PHOSPHO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHOSPHO2-to-partner and partner-to-PHOSPHO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD5-12 grouped by PHOSPHO2-low versus PHOSPHO2-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOSPHO2→partner) and Y-score (partner→PHOSPHO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	IGHD5-12 →	+1.742	+5.421	<.001	.005	3	2
READ	RN7SL578P →	+0.172	+5.039	<.001	.008	3	2
UCEC	EIF3JP1 →	+0.359	+3.105	<.001	.001	3	2
BRCA	MIR6128 →	+0.743	+8.471	<.001	.005	3	1
UCEC	IGHV1OR21-1 →	+0.957	+2.800	<.001	.005	3	1
UCEC	ANKRD49 →	+0.476	+3.234	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

IGHD5-12 by PHOSPHO2 expression — READ

Explore this box plot interactively →