PHOSPHO2

Across TCGA patient cohorts, PHOSPHO2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHOSPHO2-associated genes across cancer lineages are PDCD4, ATM, and Rab25. Each is linked with PHOSPHO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHOSPHO2-to-partner and partner-to-PHOSPHO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by PHOSPHO2-low versus PHOSPHO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOSPHO2→partner) and Y-score (partner→PHOSPHO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.715	-3.000	.008	.037	3	1
UCEC	ATM →	-0.688	-3.000	.008	.037	3	1
UCEC	Rab25 →	-0.416	-3.000	.030	.037	2	1
UCEC	Shc_pY317 →	-0.177	-3.000	.044	.037	2	1
UCEC	GSK-3_pS9 →	-0.691	-3.000	.003	.037	1	1
UCEC	p27_pT198 →	+0.130	+3.000	.036	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PDCD4 by PHOSPHO2 expression — UCEC

Explore this box plot interactively →