PHOSPHO1

Across TCGA patient cohorts, PHOSPHO1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,446 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PHOSPHO1-associated proteins across cancer lineages are VAV1, WAS, and ARHGAP25. Each is linked with PHOSPHO1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PHOSPHO1-to-partner and partner-to-PHOSPHO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHOSPHO1 versus VAV1 in GBM, with a Pearson correlation of 0.68.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOSPHO1→partner) and Y-score (partner→PHOSPHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VAV1 →	+0.634	+0.928	<.001	<.001	3	8
GBM	WAS →	+0.530	+0.878	<.001	<.001	3	8
HNSC	ARHGAP25 →	+0.558	+0.684	<.001	<.001	3	8
GBM	ARHGAP45 →	+0.545	+0.654	<.001	<.001	3	8
HNSC	ARHGAP9 →	+0.497	+0.798	<.001	<.001	3	8
LSCC	ARHGAP9_S475 →	+1.059	+0.818	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,446 associations by consensus.

PHOSPHO1 vs VAV1 — GBM

Explore this scatter interactively →