PHOSPHO1

Across TCGA patient cohorts, PHOSPHO1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,156 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PHOSPHO1-associated genes across cancer lineages are MCUR1, RNF169, and CEACAM3. Each is linked with PHOSPHO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHOSPHO1-to-partner and partner-to-PHOSPHO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHOSPHO1 versus MCUR1 in HNSC, with a Pearson correlation of -0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOSPHO1→partner) and Y-score (partner→PHOSPHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MCUR1 →	-0.908	-0.923	.001	<.001	3	2
LSCC	RNF169 →	-0.460	-0.427	.004	.003	3	2
LSCC	CEACAM3 →	+0.988	+0.574	<.001	<.001	3	2
LUAD	ZNF445 →	-0.686	-1.070	.008	.002	3	2
LUAD	UBE2E1-AS1 →	-0.400	-1.167	.006	<.001	3	2
LSCC	IFITM3P9 →	+1.291	+0.627	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,156 associations by consensus.

PHOSPHO1 vs MCUR1 — HNSC

Explore this scatter interactively →