PHOSPHO1

Across TCGA patient cohorts, PHOSPHO1 protein abundance is significantly associated with the protein abundance of many other proteins, with 1,679 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PHOSPHO1-associated proteins across cancer lineages are CRTC2_S164, METTL3_S43, and COMMD7. Each is linked with PHOSPHO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHOSPHO1-to-partner and partner-to-PHOSPHO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHOSPHO1 versus CRTC2_S164 in GBM, with a Pearson correlation of 0.83.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOSPHO1→partner) and Y-score (partner→PHOSPHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CRTC2_S164 →	+1.068	+1.209	.004	<.001	3	2
LUAD	METTL3_S43 →	+0.879	+1.168	<.001	<.001	3	2
LUAD	COMMD7 →	+0.851	+1.168	.003	<.001	3	2
LSCC	COPB1_S371 →	+0.600	+0.634	<.001	<.001	3	1
LSCC	AGFG2_T163 →	+0.728	+0.407	<.001	.002	3	1
LSCC	CRISP3 →	+0.781	+0.465	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,679 associations by consensus.

PHOSPHO1 vs CRTC2_S164 — GBM

Explore this scatter interactively →