PHOSPHO1

Across TCGA patient cohorts, PHOSPHO1 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHOSPHO1-associated genes across cancer lineages are ERK2, FOXO3a_pS318_S321, and NDRG1_pT346. Each is linked with PHOSPHO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHOSPHO1-to-partner and partner-to-PHOSPHO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PHOSPHO1-low versus PHOSPHO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHOSPHO1→partner) and Y-score (partner→PHOSPHO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.317	+3.321	.001	.010	3	2
UCEC	FOXO3a_pS318_S321 →	-0.159	-2.990	.015	.036	3	1
UCEC	NDRG1_pT346 →	-0.508	-3.000	.048	.036	3	1
UCEC	Annexin-1 →	+0.813	+2.827	.003	.035	3	1
UCEC	TIGAR →	+0.161	+2.196	.044	.034	3	1
UCEC	Cyclin-E2 →	+0.205	+3.321	.020	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ERK2 by PHOSPHO1 expression — UCEC

Explore this box plot interactively →