PHLPP2

Across TCGA patient cohorts, PHLPP2 protein abundance is significantly associated with the RNA expression of many other genes, with 1,547 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PHLPP2-associated genes across cancer lineages are RPL7P2, FAM20B, and HHLA1. Each is linked with PHLPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHLPP2-to-partner and partner-to-PHLPP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHLPP2 versus RPL7P2 in LUAD, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLPP2→partner) and Y-score (partner→PHLPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL7P2 →	+0.320	+0.427	<.001	.003	3	2
CCRCC	FAM20B →	+0.373	+0.672	<.001	<.001	3	1
CCRCC	HHLA1 →	+0.026	+0.916	.001	.009	3	1
CCRCC	SLC26A2 →	+0.614	+0.573	.002	.008	3	1
CCRCC	CBR3 →	+0.657	+0.783	<.001	<.001	3	1
CCRCC	AMFR →	+0.678	+0.647	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,547 associations by consensus.

PHLPP2 vs RPL7P2 — LUAD

Explore this scatter interactively →