PHLPP2

Across TCGA patient cohorts, PHLPP2 mutation is significantly associated with the RNA expression of many other genes, with 5,074 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLPP2-associated genes across cancer lineages are PPP2CA, YIPF5, and WDR41. Each is linked with PHLPP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHLPP2-to-partner and partner-to-PHLPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2CA grouped by PHLPP2-low versus PHLPP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLPP2→partner) and Y-score (partner→PHLPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP2CA →	+0.282	+1.764	<.001	<.001	3	4
UCEC	YIPF5 →	+0.371	+1.938	.001	.001	3	4
UCEC	WDR41 →	+0.307	+1.387	.001	.001	3	4
UCEC	LSM1 →	+0.398	+1.710	<.001	<.001	3	4
UCEC	OIP5 →	+0.870	+2.099	<.001	<.001	3	3
UCEC	EMC7 →	+0.464	+2.317	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,074 associations by consensus.

PPP2CA by PHLPP2 expression — UCEC

Explore this box plot interactively →