PHLPP2

Across TCGA patient cohorts, PHLPP2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLPP2-associated genes across cancer lineages are mTOR_pS2448, VHL, and ATM. Each is linked with PHLPP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHLPP2-to-partner and partner-to-PHLPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PHLPP2-low versus PHLPP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLPP2→partner) and Y-score (partner→PHLPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.127	-2.228	.003	.001	3	4
UCEC	VHL →	-0.787	-1.353	<.001	.013	3	3
UCEC	ATM →	-0.586	-2.146	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.147	+1.524	.002	.008	3	3
SKCM	Di-Ras3 →	+0.156	+1.906	.005	.016	3	2
UCEC	NDRG1_pT346 →	-0.306	-1.152	.031	.048	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

mTOR_pS2448 by PHLPP2 expression — UCEC

Explore this box plot interactively →