PHLPP2

Across TCGA cell cohorts, PHLPP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,034 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHLPP2-associated GO terms across cancer lineages are Nucleic acid transport, RNA transport, and mRNA export from nucleus. Each is linked with PHLPP2 in more than 16 cancer types. Because this analysis shows association rather than direction, both PHLPP2-to-partner and partner-to-PHLPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleic acid transport grouped by PHLPP2-low versus PHLPP2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLPP2→partner) and Y-score (partner→PHLPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Nucleic acid transport →	+0.117	+1.076	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	RNA transport →	+0.117	+1.076	<.001	<.001	3	17
BREAST	mRNA export from nucleus →	+0.100	+0.997	<.001	<.001	3	17
SKIN	Microtubule organizing center organization →	+0.080	+0.801	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.087	+1.029	<.001	<.001	3	16
BONE	Establishment of RNA localization →	+0.138	+1.027	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,034 associations by consensus.

Nucleic acid transport by PHLPP2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →