PHLPP2

Across TCGA cell cohorts, PHLPP2 mutation is significantly associated with the RNA expression of many other genes, with 607 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHLPP2-associated genes across cancer lineages are DCD, TNP2, and BHLHE22. Each is linked with PHLPP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHLPP2-to-partner and partner-to-PHLPP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCD grouped by PHLPP2-low versus PHLPP2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLPP2→partner) and Y-score (partner→PHLPP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DCD →	+0.063	+4.807	<.001	.006	3	1
OESOPHAGUS	TNP2 →	+0.023	+4.392	<.001	.003	3	1
OESOPHAGUS	BHLHE22 →	+0.052	+4.017	<.001	.007	3	1
SOFT_TISSUE	RPL10L →	+0.038	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR52J3 →	+0.026	+5.369	<.001	.004	3	1
SOFT_TISSUE	RBMY1E →	+1.205	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 607 associations by consensus.

DCD by PHLPP2 expression — BLOOD_Myeloma

Explore this box plot interactively →