PHLPP1

Across TCGA pan-cancer cohorts, PHLPP1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PHLPP1 data layer compared with 21 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PHLPP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PHLPP1 expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

LUAD, GBM, and HNSC are the cancer types where PHLPP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.357	0.865	.003	35	view →
GBM	OS	Tertile	All	0.649	0.350	.003	4	view →
HNSC	OS	Tertile	III,IV	0.832	0.575	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PHLPP1–LUAD (DFS)

Open the LUAD breakdown →