PHLPP1

Across TCGA patient cohorts, PHLPP1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLPP1-associated genes across cancer lineages are EGFR_pY1068, mTOR_pS2448, and PDCD4. Each is linked with PHLPP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHLPP1-to-partner and partner-to-PHLPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PHLPP1-low versus PHLPP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLPP1→partner) and Y-score (partner→PHLPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.225	-1.398	.001	.004	3	3
UCEC	mTOR_pS2448 →	-0.105	-1.494	.012	.014	3	3
UCEC	PDCD4 →	-0.438	-2.502	.001	.001	3	3
UCEC	ATM →	-0.535	-2.571	<.001	<.001	3	3
UCEC	c-Met_pY1235 →	+0.044	+1.222	.037	.011	3	3
COAD	Mre11 →	+0.167	+2.815	.010	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

EGFR_pY1068 by PHLPP1 expression — UCEC

Explore this box plot interactively →