PHLPP1

Across TCGA cell cohorts, PHLPP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,234 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHLPP1-associated GO terms across cancer lineages are Regulation of T cell anergy, Regulation of lymphocyte anergy, and Negative regulation of exosomal secretion. Each is linked with PHLPP1 in more than 10 cancer types. Because this analysis shows association rather than direction, both PHLPP1-to-partner and partner-to-PHLPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of T cell anergy grouped by PHLPP1-low versus PHLPP1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLPP1→partner) and Y-score (partner→PHLPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of T cell anergy →	-0.286	-1.438	<.001	<.001	3	11
BLOOD_Myeloma	Regulation of lymphocyte anergy →	-0.286	-1.438	<.001	<.001	3	11
KIDNEY	Negative regulation of exosomal secretion →	+0.186	+0.608	.002	.007	3	9
BLOOD_Leukemia	Regulation of nucleotide-excision repair →	+0.118	+1.411	<.001	<.001	3	9
SOFT_TISSUE	Regulation of tolerance induction →	-0.219	-1.077	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Host-mediated perturbation of viral transcription →	+0.099	+1.171	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,234 associations by consensus.

Regulation of T cell anergy by PHLPP1 expression — BLOOD_Myeloma

Explore this box plot interactively →