PHLPP1

Across TCGA cell cohorts, PHLPP1 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHLPP1-associated genes across cancer lineages are TFDP3, ASB17, and VWC2. Each is linked with PHLPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHLPP1-to-partner and partner-to-PHLPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by PHLPP1-low versus PHLPP1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLPP1→partner) and Y-score (partner→PHLPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TFDP3 →	+0.013	+5.000	<.001	.006	3	2
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	2
BLOOD_Leukemia	VWC2 →	+0.397	+4.551	.002	.004	3	2
OESOPHAGUS	TNP2 →	+0.023	+4.392	<.001	.003	3	1
OESOPHAGUS	BHLHE22 →	+0.043	+4.017	<.001	.007	3	1
PANCREAS	CCDC105 →	+0.013	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

TFDP3 by PHLPP1 expression — PANCREAS

Explore this box plot interactively →