PHLDB3

Across TCGA patient cohorts, PHLDB3 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,790 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PHLDB3-associated proteins across cancer lineages are PHLDB3_S254, ICAM1, and IRF2BP1_S384. Each is linked with PHLDB3 in more than 5 cancer types. Because this analysis shows association rather than direction, both PHLDB3-to-partner and partner-to-PHLDB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHLDB3 versus PHLDB3_S254 in HNSC, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB3→partner) and Y-score (partner→PHLDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PHLDB3_S254 →	+0.716	+0.753	<.001	<.001	3	6
BRCA	ICAM1 →	-0.563	-0.644	<.001	<.001	3	4
BRCA	IRF2BP1_S384 →	+0.452	+0.576	<.001	<.001	3	4
GBM	MED29 →	+0.236	+0.426	<.001	<.001	3	4
OV	MDM1_S601 →	+0.833	+0.589	.003	.003	3	4
COAD	PARP14 →	-0.378	-0.532	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,790 associations by consensus.

PHLDB3 vs PHLDB3_S254 — HNSC

Explore this scatter interactively →