PHLDB3

Across TCGA patient cohorts, PHLDB3 protein abundance is significantly associated with the RNA expression of many other genes, with 8,511 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PHLDB3-associated genes across cancer lineages are IFI30, LGALSL, and TTC9. Each is linked with PHLDB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both PHLDB3-to-partner and partner-to-PHLDB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHLDB3 versus IFI30 in BRCA, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB3→partner) and Y-score (partner→PHLDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IFI30 →	-0.556	-0.403	<.001	<.001	3	4
UCEC	LGALSL →	+0.838	+0.350	<.001	.002	3	3
UCEC	TTC9 →	+0.846	+0.312	<.001	<.001	3	3
BRCA	ARHGAP32 →	+0.868	+0.426	<.001	<.001	3	3
LSCC	ZNF750 →	+1.070	+0.569	<.001	<.001	3	3
UCEC	SLFN11 →	-0.881	-0.471	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,511 associations by consensus.

PHLDB3 vs IFI30 — BRCA

Explore this scatter interactively →