PHLDB3

Across TCGA patient cohorts, PHLDB3 protein abundance is significantly associated with the protein abundance of many other proteins, with 10,697 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PHLDB3-associated proteins across cancer lineages are PHLDB3_S254, EPN3_S192, and ARAF. Each is linked with PHLDB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PHLDB3-to-partner and partner-to-PHLDB3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PHLDB3 versus PHLDB3_S254 in LSCC, with a Pearson correlation of 0.72.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB3→partner) and Y-score (partner→PHLDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PHLDB3_S254 →	+0.815	+0.716	<.001	<.001	3	5
LSCC	EPN3_S192 →	+1.282	+0.789	<.001	<.001	3	4
HNSC	ARAF →	-0.245	-0.571	<.001	<.001	3	4
LSCC	CRYBG2 →	+0.823	+0.548	<.001	<.001	3	3
HNSC	CTNNBIP1 →	+0.629	+0.490	<.001	<.001	3	3
HNSC	DLG5 →	+0.335	+0.548	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,697 associations by consensus.

PHLDB3 vs PHLDB3_S254 — LSCC

Explore this scatter interactively →