PHLDB3

Across TCGA patient cohorts, PHLDB3 mutation is significantly associated with the RNA expression of many other genes, with 1,544 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLDB3-associated genes across cancer lineages are OR52Z1, RN7SL584P, and LINC00850. Each is linked with PHLDB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PHLDB3-to-partner and partner-to-PHLDB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52Z1 grouped by PHLDB3-low versus PHLDB3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB3→partner) and Y-score (partner→PHLDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR52Z1 →	+0.062	+5.332	<.001	.002	3	3
HNSC	RN7SL584P →	+0.295	+5.763	<.001	.001	3	3
SKCM	LINC00850 →	+0.019	+3.328	<.001	.004	3	2
CESC	VN2R3P →	+0.030	+4.384	<.001	.008	3	2
BLCA	LINC02706 →	+0.095	+6.048	<.001	<.001	3	2
BLCA	MIR3927 →	+0.307	+4.433	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,544 associations by consensus.

OR52Z1 by PHLDB3 expression — COAD

Explore this box plot interactively →