PHLDB3

Across TCGA patient cohorts, PHLDB3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHLDB3-associated genes across cancer lineages are STAT3_pY705, 4E-BP1, and EGFR_pY1068. Each is linked with PHLDB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHLDB3-to-partner and partner-to-PHLDB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by PHLDB3-low versus PHLDB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB3→partner) and Y-score (partner→PHLDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.412	-3.807	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.293	+2.199	.016	.033	3	2
UCEC	EGFR_pY1068 →	-0.241	-2.700	.033	.006	3	1
UCEC	Fibronectin →	-0.346	-2.000	.019	.032	3	1
UCEC	JNK2 →	+0.236	+3.179	.008	.010	3	1
UCEC	Ku80 →	+0.359	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

STAT3_pY705 by PHLDB3 expression — UCEC

Explore this box plot interactively →