PHLDB3

Across TCGA cell cohorts, PHLDB3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,338 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PHLDB3-associated GO terms across cancer lineages are Negative regulation of calcium ion export across plasma membrane, Phospholipid biosynthetic process, and Cytosolic transport. Each is linked with PHLDB3 in more than 12 cancer types. Because this analysis shows association rather than direction, both PHLDB3-to-partner and partner-to-PHLDB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion export across plasma membrane grouped by PHLDB3-low versus PHLDB3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PHLDB3→partner) and Y-score (partner→PHLDB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.094	+1.323	<.001	<.001	3	13
URINARY_TRACT	Phospholipid biosynthetic process →	+0.043	+1.114	.002	.007	3	12
KIDNEY	Cytosolic transport →	+0.067	+1.083	.002	.002	3	12
KIDNEY	Regulation of protein localization to endoplasmic reticulum →	+0.117	+1.061	.008	.006	3	12
KIDNEY	Negative regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.094	+1.538	.004	<.001	3	12
LARGE_INTESTINE	Response to starvation →	+0.049	+1.115	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,338 associations by consensus.

Negative regulation of calcium ion export across plasma membrane by PHLDB3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →