PHLDB1

Across TCGA pan-cancer cohorts, PHLDB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PHLDB1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PHLDB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PHLDB1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LSCC, CCRCC, and LUAD are the cancer types where PHLDB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.830	1.000	.003	15	view →
CCRCC	OS	Median	IV	0.451	1.000	.016	13	view →
LUAD	OS	Median	III,IV	0.678	0.213	.006	5	view →
GBM	OS	Median	All	0.387	0.645	.024	4	view →
PDAC	DFS	Tertile	II,III,IV	0.837	0.667	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PHLDB1–LSCC (DFS)

Open the LSCC breakdown →