PHKG2

Across TCGA patient cohorts, PHKG2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHKG2-associated genes across cancer lineages are ERK2, GAPDH, and c-Met_pY1235. Each is linked with PHKG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHKG2-to-partner and partner-to-PHKG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PHKG2-low versus PHKG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHKG2→partner) and Y-score (partner→PHKG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.242	+3.087	.001	<.001	3	2
UCEC	GAPDH →	+0.517	+2.415	.016	.003	3	2
UCEC	c-Met_pY1235 →	+0.080	+2.415	.007	.003	3	2
UCEC	Cyclin-B1 →	+0.613	+3.321	.006	.010	3	2
UCEC	eEF2 →	+0.356	+2.459	.013	.019	3	1
UCEC	eIF4G →	+0.310	+3.459	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

ERK2 by PHKG2 expression — UCEC

Explore this box plot interactively →