PHKG2

Across TCGA cell cohorts, PHKG2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible PHKG2-associated genes across cancer lineages are H2BW1, SMIM36, and RESP18. Each is linked with PHKG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHKG2-to-partner and partner-to-PHKG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW1 grouped by PHKG2-low versus PHKG2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHKG2→partner) and Y-score (partner→PHKG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	H2BW1 →	+0.208	+4.977	<.001	.007	3	1
SKIN	SMIM36 →	+0.183	+4.977	<.001	.007	3	1
OVARY	RESP18 →	+0.038	+5.196	<.001	.005	3	1
OVARY	IFNA2 →	+0.020	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

H2BW1 by PHKG2 expression — SKIN

Explore this box plot interactively →