PHKG1

Across TCGA patient cohorts, PHKG1 mutation is significantly associated with the RNA expression of many other genes, with 549 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PHKG1-associated genes across cancer lineages are LINC01974, HMGB1P29, and PDP2. Each is linked with PHKG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHKG1-to-partner and partner-to-PHKG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01974 grouped by PHKG1-low versus PHKG1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHKG1→partner) and Y-score (partner→PHKG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LINC01974 →	+0.089	+5.578	<.001	.004	3	2
LUAD	HMGB1P29 →	+0.135	+3.605	<.001	<.001	3	2
UCEC	PDP2 →	+0.530	+2.649	<.001	<.001	3	2
LUSC	USP17L3 →	+0.039	+7.924	<.001	.008	3	2
UCEC	COX6CP12 →	+0.066	+2.997	.003	.006	3	2
UCEC	RNA5SP419 →	+0.691	+2.077	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 549 associations by consensus.

LINC01974 by PHKG1 expression — HNSC

Explore this box plot interactively →