PHKG1

Across TCGA cell cohorts, PHKG1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PHKG1-associated genes across cancer lineages are PRSS54, CRYGC, and CSN3. Each is linked with PHKG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PHKG1-to-partner and partner-to-PHKG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by PHKG1-low versus PHKG1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PHKG1→partner) and Y-score (partner→PHKG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.030	+3.345	<.001	.001	3	1
BLOOD_Leukemia	CRYGC →	+0.017	+3.969	.002	.009	3	1
BLOOD_Leukemia	CSN3 →	+0.022	+3.475	<.001	.006	3	1
BLOOD_Leukemia	TPRX1 →	+0.014	+3.475	<.001	.006	3	1
BLOOD_Leukemia	NKX2-6 →	+0.337	+4.201	<.001	.001	3	1
BLOOD_Leukemia	PRR30 →	+0.015	+3.684	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PRSS54 by PHKG1 expression — LARGE_INTESTINE

Explore this box plot interactively →