PHKBP2

Across TCGA pan-cancer cohorts, PHKBP2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of PHKBP2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PHKBP2 RNA is repressed in tumor relative to normal tissue. In most cancer types PHKBP2 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

LUSC and LUAD are the cancer types where PHKBP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PHKBP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	−0.040	<.001	5	view →
LUAD	All	III,IV	+0.100	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

PHKBP2–LUSC

Open the LUSC breakdown →